All of our experimental and precision medicine-focused research depends upon accurate and detailed human phenotyping information and experimental systems that allow us to validate mechanistic hypotheses in the context of human cells and the relevant genetic background. Our group operates and utilizes the following resources to enable cutting edge research with human samples.
Human Model Systems: We utilize primary human cells from disease affected patients and healthy subjects to generate induced pluripotent stem cells which can then be used in experiments to test mechanistic hypotheses in in vitro and humanized animal models.
Biorepository: Our groups work intimately with both the Oklahoma Rheumatic Disease Clinic and the Multiple Sclerosis Center of Excellence to develop and expand the clinical collections that will be most valuable for future experimental research and enable collection of the most informative information about the subjects in these collections.